Description
A selective Nav1.1 and Nav1.3 channel blocker (IC50s = 10,000 nM for Nav1.1, Nav1.3, Nav1.4, and Nav1.5-1.8, respectively); induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at 1 µM; substitution of the Nav1.3 VSD4 with the Nav1.5 VSD4 reduces potency by ~500-fold